Shared lexical access processes in speaking and listening? An individual differences study

- * indicates joint first authorship - Lexical access is a core component of word processing. In order to produce or comprehend a word, language users must access word forms in their mental lexicon. However, despite its involvement in both tasks, previous research has often studied lexical access in either production or comprehension alone. Therefore, it is unknown to which extent lexical access processes are shared across both tasks. Picture naming and auditory lexical decision are considered good tools for studying lexical access. Both of them are speeded tasks. Given these commonalities, another open question concerns the involvement of general cognitive abilities (e.g., processing speed) in both linguistic tasks. In the present study, we addressed these questions. We tested a large group of young adults enrolled in academic and vocational courses. Participants completed picture naming and auditory lexical decision tasks as well as a battery of tests assessing non-verbal processing speed, vocabulary, and non-verbal intelligence. Our results suggest that the lexical access processes involved in picture naming and lexical decision are related but less closely than one might have thought. Moreover, reaction times in picture naming and lexical decision depended as least as much on general processing speed as on domain-specific linguistic processes (i.e., lexical access processes)

Loss of H3K27 methylation identifies poor outcomes in adult-onset acute leukemia

BackgroundAcute leukemia is an epigenetically heterogeneous disease. The intensity of treatment is currently guided by cytogenetic and molecular genetic risk classifications; however these incompletely predict outcomes, requiring additional information for more accurate outcome predictions. We aimed to identify potential prognostic implications of epigenetic modification of histone proteins, with a focus on H3K4 and H3K27 methylation marks in relation to mutations in chromatin, splicing and transcriptional regulators in adult-onset acute lymphoblastic and myeloid leukemia.ResultsHistone 3 lysine 4 di- and trimethylation (H3K4me2, H3K4me3) and lysine 27 trimethylation (H3K27me3) mark expression was evaluated in 241 acute myeloid leukemia (AML), 114 B-cell acute lymphoblastic leukemia (B-ALL) and 14T-cell ALL (T-ALL) patient samples at time of diagnosis using reverse phase protein array. Expression levels of the marks were significantly lower in AML than in B and T-ALL in both bone marrow and peripheral blood, as well as compared to normal CD34+ cells. In AML, greater loss of H3K27me3 was associated with increased proliferative potential and shorter overall survival in the whole patient population, as well as in subsets with DNA methylation mutations. To study the prognostic impact of H3K27me3 in the context of cytogenetic aberrations and mutations, multivariate analysis was performed and identified lower H3K27me3 level as an independent unfavorable prognostic factor in all, as well as in TP53 mutated patients. AML with decreased H3K27me3 demonstrated an upregulated anti-apoptotic phenotype. In ALL, the relative quantity of histone methylation expression correlated with response to tyrosine kinase inhibitor in patients who carried the Philadelphia cytogenetic aberration and prior smoking behavior.ConclusionThis study shows that proteomic profiling of epigenetic modifications has clinical implications in acute leukemia and supports the idea that epigenetic patterns contribute to a more accurate picture of the leukemic state that complements cytogenetic and molecular genetic subgrouping. A combination of these variables may offer more accurate outcome prediction and we suggest that histone methylation mark measurement at time of diagnosis might be a suitable method to improve patient outcome prediction and subsequent treatment intensity stratification in selected subgroups

The power-capture of a nearshore, modular, flap-type wave energy converter in regular waves

Bottom-hinged, nearshore flap-type wave energy converters (WECs), have several advantages, such as high power conversion efficiency and survivability. They typically comprise a single flap spanning their full width. However, a potentially beneficial design change would be to split the flap into multiple modules, to make a ‘Modular Flap’. This could provide improvements, such as increased power-capture, reduced foundation loads and lower manufacturing and installation costs. Assessed in this work is the hydrodynamic power-capture of this device, based on physical modelling. Comparisons are made to an equivalent ‘Rigid Flap’. Tests are conducted in regular, head-on and off-angle waves. The simplest control strategy, of damping each module equally, is employed. The results show that, for head-on waves, the power increases towards the centre of the device, with the central modules generating 68% of the total power. Phase differences are also present. Consequently, the total power produced by the Modular Flap is, on average, 23% more smooth than that generated by the Rigid Flap. The Modular Flap has 3% and 1% lower average power-capture than the Rigid Flap in head-on and off-angle waves, respectively. The advantages of the modular concept may therefore be exploited without significantly compromising the power-capture of the flap-type WEC